This study evaluated the ability of ethanol extract of Aframomum angustifolium seeds to ameliorate the nephrotoxic effect of potassium bromate (KBrO3) in rats. Biochemical alterations following co-administration of extract with 30 mg/kgbw KBrO3 were monitored in four animal groups (3 rats/group). Oral administration lasted for 28 days. Biomarkers were monitored using standard spectrophotometric methods. Kidney SOD and CAT activities, as well as serum HCO3- and creatinine levels were significantly lower (p<0.05) in the treated groups than in the positive control group. Photomicrographs of kidney tissue support the biochemical observations. These findings suggest that the extract mitigated bromate-induced kidney lesions in the treated rats.
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